• Target：
• Rabenosyn-5

• Fields：
• >>Endocytosis

• Gene Name：
• ZFYVE20

• Protein Name：
• Rabenosyn-5

• Human Gene Id：
• 64145

• Human Swiss Prot No：
• Q9H1K0

• Mouse Gene Id：
• 78287

• Mouse Swiss Prot No：
• Q80Y56

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ZFYVE20. AA range:145-194

• Specificity：
• Rabenosyn-5 Polyclonal Antibody detects endogenous levels of Rabenosyn-5 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ZFYVE20;Rabenosyn-5;110 kDa protein;FYVE finger-containing Rab5 effector protein rabenosyn-5;Zinc finger FYVE domain-containing protein 20

• Observed Band(KD)：
• 89kD

• Background：
• This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],

• Function：
• function:Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 UIM (ubiquitin-interacting motif) repeat.,subunit:Interacts with EHD1, RAB4A, RAB5A, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding.,

• Subcellular Location：
• Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane ; Lipid-anchor. Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. .

• Expression：
• Brain,Cervix carcinoma,Epithelium,Human salivary gland,

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