• Target：
• Rag C

• Fields：
• >>Autophagy - animal;>>mTOR signaling pathway;>>Shigellosis

• Gene Name：
• RRAGC

• Protein Name：
• Ras-related GTP-binding protein C

• Human Gene Id：
• 64121

• Human Swiss Prot No：
• Q9HB90

• Mouse Gene Id：
• 54170

• Mouse Swiss Prot No：
• Q99K70

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human RRAGC. AA range:302-351

• Specificity：
• Rag C Polyclonal Antibody detects endogenous levels of Rag C protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; IP 1:50-200 ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RRAGC;Ras-related GTP-binding protein C;Rag C;RagC;GTPase-interacting protein 2;TIB929

• Observed Band(KD)：
• 44kD

• Background：
• This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],

• Function：
• function:Has guanine nucleotide-binding activity but weak intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.,subunit:Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB.,

• Subcellular Location：
• Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). .

• Expression：
• Lymph,Ovary,

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop CoIP Human /SW620, HCT116 Cells

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