RASSF2 Polyclonal Antibody

    • Catalog No.:YT4011
    • Applications:WB;IHC
    • Reactivity:Human;Mouse;Rat
      • Target:
      • RASSF2
      • Fields:
      • >>Hippo signaling pathway - multiple species
      • Gene Name:
      • RASSF2
      • Protein Name:
      • Ras association domain-containing protein 2
      • Human Gene Id:
      • 9770
      • Human Swiss Prot No:
      • P50749
      • Mouse Swiss Prot No:
      • Q8BMS9
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human RASSF2. AA range:109-158
      • Specificity:
      • RASSF2 Polyclonal Antibody detects endogenous levels of RASSF2 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC-p 1:50-300
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • RASSF2;KIAA0168;Ras association domain-containing protein 2
      • Observed Band(KD):
      • 36kD
      • Background:
      • This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.,
      • Subcellular Location:
      • Nucleus. Cytoplasm. Chromosome, centromere, kinetochore . Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.
      • Expression:
      • Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
      • Products Images
      • Western blot analysis of lysates from Jurkat cells, using RASSF2 Antibody. The lane on the right is blocked with the synthesized peptide.
      • Western blot analysis of the lysates from HepG2 cells using RASSF2 antibody.
      • Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).