RXRγ Polyclonal Antibody

    • Catalog No.:YT4195
    • Applications:WB;IHC;IF;ELISA
    • Reactivity:Human;Mouse
      • Target:
      • RXRγ
      • Fields:
      • >>PPAR signaling pathway;>>Th17 cell differentiation;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Chemical carcinogenesis - receptor activation;>>Thyroid cancer;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Gastric cancer;>>Lipid and atherosclerosis
      • Gene Name:
      • RXRG
      • Protein Name:
      • Retinoic acid receptor RXR-gamma
      • Human Gene Id:
      • 6258
      • Human Swiss Prot No:
      • P48443
      • Mouse Swiss Prot No:
      • P28705
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human Retinoid X Receptor gamma. AA range:171-220
      • Specificity:
      • RXRγ Polyclonal Antibody detects endogenous levels of RXRγ protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • RXRG;NR2B3;Retinoic acid receptor RXR-gamma;Nuclear receptor subfamily 2 group B member 3;Retinoid X receptor gamma
      • Observed Band(KD):
      • 50kD
      • Background:
      • retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],
      • Function:
      • caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,
      • Subcellular Location:
      • Nucleus . Cytoplasm .
      • Expression:
      • Expressed in aortic endothelial cells (at protein level).
      • Products Images
      • Western Blot analysis of various cells using RXRγ Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Western Blot analysis of HepG2 cells using RXRγ Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval.
      • Immunofluorescence analysis of HUVEC cells, using Retinoid X Receptor gamma Antibody. The picture on the right is blocked with the synthesized peptide.
      • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Retinoid X Receptor gamma Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from HepG2 cells, using Retinoid X Receptor gamma Antibody. The lane on the right is blocked with the synthesized peptide.