SDHA Polyclonal Antibody

  • Catalog No.：YT4226
  • Applications：WB;IHC
  • Reactivity：Human;Mouse;Rat
    • Target：
    • SDHA
    • Fields：
    • >>Citrate cycle (TCA cycle);>>Oxidative phosphorylation;>>Metabolic pathways;>>Carbon metabolism;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy
    • Gene Name：
    • SDHA
    • Protein Name：
    • Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial
    • Human Gene Id：
    • 6389
    • Human Swiss Prot No：
    • P31040
    • Mouse Swiss Prot No：
    • Q8K2B3
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human SDHA. AA range:551-600
    • Specificity：
    • SDHA Polyclonal Antibody detects endogenous levels of SDHA protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000;IHC 1:50-300
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • SDHA;SDH2;SDHF;Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial;Flavoprotein subunit of complex II;Fp
    • Observed Band(KD)：
    • 70kD
    • Background：
    • This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
    • Function：
    • catalytic activity:Succinate + ubiquinone = fumarate + ubiquinol.,cofactor:FAD.,disease:Defects in SDHA are a cause of complex II mitochondrial respiratory chain deficiency [MIM:252011]; also known as succinate CoQ reductase deficiency. Defects of oxidative phosphorylation give rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. A deficiency of complex II represents a rare cause of mitochondrial encephalomyopathy, leukodystrophy, late-onset optic atrophy and ataxia, myopathy with exercise intolerance, and isolated cardiomyopathy.,disease:Defects in SDHA are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.,function:Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electr
    • Subcellular Location：
    • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
    • Expression：
    • Adipocyte,Brain,Colon,Heart,Liver,Placenta,

    Attributes

    • Code：
    • YT4226
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-23
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