• Target：
• Six1

• Fields：
• >>Transcriptional misregulation in cancer

• Gene Name：
• SIX1

• Protein Name：
• Homeobox protein SIX1

• Human Gene Id：
• 6495

• Human Swiss Prot No：
• Q15475

• Mouse Gene Id：
• 20471

• Mouse Swiss Prot No：
• Q62231

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SIX1. AA range:111-160

• Specificity：
• Six1 Polyclonal Antibody detects endogenous levels of Six1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SIX1;Homeobox protein SIX1;Sine oculis homeobox homolog 1

• Observed Band(KD)：
• 33kD

• Background：
• The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in SIX1 are the cause of autosomal dominant deafness type 23 (DFNA23) [MIM:605192].,disease:Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3) [MIM:608389]. Urinary tract malformations constitute the most frequent cause of chronic renal failure in the first two decades of life. Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder of kidney and urinary tract malformations with hearing loss. The major feature of BOR is hearing loss (93% of patients), which can be conductive, sensorineural, or both and varies in age of onset.,function:May be involved in limb tendon and ligament development.,similarity:Belongs to the SIX/Sine oculis homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Specifically expressed in skeletal muscle.,

• Subcellular Location：
• Nucleus . Cytoplasm.

• Expression：
• Specifically expressed in skeletal muscle.

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