StIp1 Polyclonal Antibody

    • Catalog No.:YT4459
    • Applications:WB;IHC
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • StIp1
      • Gene Name:
      • ELP2
      • Protein Name:
      • Elongator complex protein 2
      • Human Swiss Prot No:
      • Q6IA86
      • Mouse Swiss Prot No:
      • Q91WG4
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human ELP2. AA range:771-820
      • Specificity:
      • StIp1 Polyclonal Antibody detects endogenous levels of StIp1 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC 1:50-300
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • ELP2;STATIP1;Elongator complex protein 2;ELP2;SHINC-2;STAT3-interacting protein 1;StIP1
      • Observed Band(KD):
      • 93kD
      • Background:
      • The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016],
      • Function:
      • function:Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.,function:Regulates the ligand-dependent activation of STAT3.,similarity:Belongs to the WD repeat ELP2 family.,similarity:Contains 14 WD repeats.,subunit:Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs.,
      • Subcellular Location:
      • Cytoplasm . Nucleus .
      • Expression:
      • Hematopoietic,Liver,Ovary,Uterus,
      • Products Images
      • Western Blot analysis of various cells using StIp1 Polyclonal Antibody
      • Western blot analysis of lysates from HT-29 cells, using ELP2 Antibody. The lane on the right is blocked with the synthesized peptide.
      • Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).