• Target：
• T2R49

• Fields：
• >>Taste transduction

• Gene Name：
• TAS2R20

• Protein Name：
• Taste receptor type 2 member 20

• Human Gene Id：
• 259295

• Human Swiss Prot No：
• P59543

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TAS2R49. AA range:94-143

• Specificity：
• T2R49 Polyclonal Antibody detects endogenous levels of T2R49 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TAS2R20;TAS2R49;Taste receptor type 2 member 20;Taste receptor type 2 member 49;T2R49;Taste receptor type 2 member 56;T2R56

• Observed Band(KD)：
• 38kD

• Background：
• This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016],

• Function：
• function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.,

• Subcellular Location：
• Membrane; Multi-pass membrane protein.

• Expression：
• Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

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