• Target：
• TAFI

• Fields：
• >>Complement and coagulation cascades;>>Pancreatic secretion;>>Protein digestion and absorption

• Gene Name：
• CPB2

• Protein Name：
• Carboxypeptidase B2

• Human Gene Id：
• 1361

• Human Swiss Prot No：
• Q96IY4

• Mouse Swiss Prot No：
• Q9JHH6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CPB2. AA range:321-370

• Specificity：
• TAFI Polyclonal Antibody detects endogenous levels of TAFI protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CPB2;Carboxypeptidase B2;Carboxypeptidase U;CPU;Plasma carboxypeptidase B;pCPB;Thrombin-activable fibrinolysis inhibitor;TAFI

• Observed Band(KD)：
• 48kD

• Background：
• Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],

• Function：
• catalytic activity:Release of C-terminal Arg and Lys from a polypeptide.,cofactor:Binds 1 zinc ion per subunit.,function:Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Plasma; synthesized in the liver.,

• Subcellular Location：
• Secreted.

• Expression：
• Plasma; synthesized in the liver.

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