• Target：
• TEF-1

• Fields：
• >>Hippo signaling pathway;>>Hippo signaling pathway - multiple species

• Gene Name：
• TEAD1

• Protein Name：
• Transcriptional enhancer factor TEF-1

• Human Gene Id：
• 7003

• Human Swiss Prot No：
• P28347

• Mouse Gene Id：
• 21676

• Mouse Swiss Prot No：
• P30051

• Immunogen：
• Synthesized peptide derived from TEF-1 . at AA range: 30-110

• Specificity：
• TEF-1 Polyclonal Antibody detects endogenous levels of TEF-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TEAD1;TCF13;TEF1;Transcriptional enhancer factor TEF-1;NTEF-1;Protein GT-IIC;TEA domain family member 1;TEAD-1;Transcription factor 13;TCF-13

• Observed Band(KD)：
• 50kD

• Background：
• This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010],

• Function：
• disease:Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.,function:Binds specifically and cooperatively to the SPH and GT-IIC "enhansons" (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.,similarity:Contains 1 TEA DNA-binding domain.,tissue specificity:Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.,

• Subcellular Location：
• Nucleus.

• Expression：
• Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

A yes-associated protein 1-Notch1 positive feedback loop promotes breast cancer lung metastasis by attenuating the Bone morphogenetic protein 4-SMAD family member 1/5 signaling

人 TEAD1/3/4抗体均购自美国 Immunoway 公司,人 GAPDH 抗体、蛋白 A/G-PLUS-琼脂糖(sc-2003)均

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