• Target：
• TMEM16A

• Gene Name：
• ANO1

• Protein Name：
• Anoctamin-1

• Human Gene Id：
• 55107

• Human Swiss Prot No：
• Q5XXA6

• Mouse Swiss Prot No：
• Q8BHY3

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TM16A. AA range:921-970

• Specificity：
• TMEM16A Polyclonal Antibody detects endogenous levels of TMEM16A protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ANO1;DOG1;ORAOV2;TAOS2;TMEM16A;Anoctamin-1;Discovered on gastrointestinal stromal tumors protein 1;Oral cancer overexpressed protein 2;Transmembrane protein 16A;Tumor-amplified and overexpressed sequence 2

• Molecular Weight(Da)：
• 114kD

• Background：
• domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,

• Function：
• domain:The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.,function:Acts as a calcium-activated chloride channel. Required for normal tracheal development.,similarity:Belongs to the anoctamin family.,tissue specificity:Broadly expressed with higher levels in liver and skeletal muscle.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Cytoplasm . Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors. .

• Expression：
• Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.

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