• Target：
• TPX2

• Gene Name：
• TPX2

• Protein Name：
• Targeting protein for Xklp2

• Human Gene Id：
• 22974

• Human Swiss Prot No：
• Q9ULW0

• Mouse Gene Id：
• 72119

• Mouse Swiss Prot No：
• A2APB8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DIL-2. AA range:301-350

• Specificity：
• TPX2 Polyclonal Antibody detects endogenous levels of TPX2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TPX2;C20orf1;C20orf2;DIL2;HCA519;Targeting protein for Xklp2;Differentially expressed in cancerous and non-cancerous lung cells 2;DIL-2;Hepatocellular carcinoma-associated antigen 519;Protein fls353;Restricted expression prolifera

• Observed Band(KD)：
• 86kD

• Background：
• developmental stage:Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus.,tissue specificity:Expressed in lung carcinoma cell lines but not in normal lung tissues.,

• Function：
• developmental stage:Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus.,tissue specificity:Expressed in lung carcinoma cell lines but not in normal lung tissues.,

• Subcellular Location：
• Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. .

• Expression：
• Expressed in lung carcinoma cell lines but not in normal lung tissues.

Knockdown of circ_0003340 induces cell apoptosis, inhibits invasion and proliferation through miR-564/TPX2 in esophageal cancer cells. EXPERIMENTAL CELL RESEARCH Exp Cell Res. 2020 Sep;394:112142 WB Human 1:2000 EC1 cell, EC9706 cell

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