• Target：
• TReP-132

• Gene Name：
• TRERF1

• Protein Name：
• Transcriptional-regulating factor 1

• Human Gene Id：
• 55809

• Human Swiss Prot No：
• Q96PN7

• Mouse Gene Id：
• 224829

• Mouse Swiss Prot No：
• Q8BXJ2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TREF1. AA range:1071-1120

• Specificity：
• TReP-132 Polyclonal Antibody detects endogenous levels of TReP-132 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TRERF1;BCAR2;RAPA;TREP132;Transcriptional-regulating factor 1;Breast cancer anti-estrogen resistance 2;Transcriptional-regulating protein 132;Zinc finger protein rapa;Zinc finger transcription factor TReP-132

• Molecular Weight(Da)：
• 132kD

• Background：
• This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],

• Function：
• function:Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.,similarity:Contains 1 ELM2 domain.,similarity:Contains 1 SANT domain.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with CREBBP and EP300.,tissue specificity:Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic HepG2 and HK293 cells.,

• Subcellular Location：
• Nucleus .

• Expression：
• Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic Hep-G2 and HEK293 cells.

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