• Target：
• TROP-2

• Gene Name：
• TACSTD2

• Protein Name：
• Tumor-associated calcium signal transducer 2

• Human Gene Id：
• 4070

• Human Swiss Prot No：
• P09758

• Mouse Gene Id：
• 56753

• Mouse Swiss Prot No：
• Q8BGV3

• Rat Gene Id：
• 494343

• Rat Swiss Prot No：
• Q6P9Z6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TACD2. AA range:131-180

• Specificity：
• TROP-2 Polyclonal Antibody detects endogenous levels of TROP-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TACSTD2;GA733-1;M1S1;TROP2;Tumor-associated calcium signal transducer 2;Cell surface glycoprotein Trop-2;Membrane component chromosome 1 surface marker 1;Pancreatic carcinoma marker protein GA733-1

• Observed Band(KD)：
• 35kD

• Background：
• This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009],

• Function：
• disease:Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment.,function:GA733 tumor-associated antigen gene family may function as growth factor receptors.,PTM:The N-terminus is blocked.,similarity:Contains 1 thyroglobulin type-1 domain.,tissue specificity:Placenta, pancreatic carcinoma cell lines.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Placenta, pancreatic carcinoma cell lines.

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