• Target：
• UBE2G1

• Fields：
• >>Ubiquitin mediated proteolysis;>>Protein processing in endoplasmic reticulum;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases

• Gene Name：
• UBE2G1

• Protein Name：
• Ubiquitin-conjugating enzyme E2 G1

• Human Gene Id：
• 7326

• Human Swiss Prot No：
• P62253

• Mouse Gene Id：
• 67128

• Mouse Swiss Prot No：
• P62254

• Rat Gene Id：
• 64631

• Rat Swiss Prot No：
• P62255

• Immunogen：
• Synthesized peptide derived from the Internal region of human UBE2G1.

• Specificity：
• UBE2G1 Polyclonal Antibody detects endogenous levels of UBE2G1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• UBE2G1;UBE2G;Ubiquitin-conjugating enzyme E2 G1;E217K;UBC7;Ubiquitin carrier protein G1;Ubiquitin-protein ligase G1

• Molecular Weight(Da)：
• 20kD

• Background：
• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,tissue specificity:Widely expressed, mainly in skeletal muscle.,

• Subcellular Location：
• cytoplasm,extracellular exosome,

• Expression：
• Widely expressed, mainly in skeletal muscle.

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