• Target：
• VAMP-1/2/3

• Fields：
• >>SNARE interactions in vesicular transport

• Gene Name：
• VAMP1/VAMP2/VAMP3

• Protein Name：
• Vesicle-associated membrane protein 1/2/3

• Human Gene Id：
• 6843/6844/9341

• Human Swiss Prot No：
• P23763/P63027/Q15836

• Mouse Gene Id：
• 22317/22318/22319

• Rat Gene Id：
• 25624/24803/29528

• Rat Swiss Prot No：
• Q63666/P63045/P63025

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human VAMP-1/2/3. AA range:21-70

• Specificity：
• VAMP-1/2/3 Polyclonal Antibody detects endogenous levels of VAMP-1/2/3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• VAMP1;SYB1;Vesicle-associated membrane protein 1;VAMP-1;Synaptobrevin-1;VAMP2;SYB2;Vesicle-associated membrane protein 2;VAMP-2;Synaptobrevin-2;VAMP3;SYB3;Vesicle-associated membrane protein 3;VAMP-3;Cellubrevin;CEB;Synaptob

• Observed Band(KD)：
• 13kD

• Background：
• Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014],

• Function：
• function:Involved in the targeting and/or fusion of transport vesicles to their target membrane.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subunit:Interacts with VAPA and VAPB.,tissue specificity:Nervous system, skeletal muscle and adipose tissue.,

• Subcellular Location：
• [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 2]: Cytoplasmic vesicle membrane ; Single-pass type IV membrane protein . Cell junction, synapse, synaptosome .; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein .

• Expression：
• Nervous system, skeletal muscle and adipose tissue.

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