• Target：
• VAV2

• Fields：
• >>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Focal adhesion;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Yersinia infection;>>Proteoglycans in cancer;>>Lipid and atherosclerosis

• Gene Name：
• VAV2

• Protein Name：
• Guanine nucleotide exchange factor VAV2

• Human Gene Id：
• 7410

• Human Swiss Prot No：
• P52735

• Mouse Gene Id：
• 22325

• Mouse Swiss Prot No：
• Q60992

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human VAV2. AA range:108-157

• Specificity：
• Vav2 Polyclonal Antibody detects endogenous levels of Vav2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• VAV2;Guanine nucleotide exchange factor VAV2;VAV-2

• Observed Band(KD)：
• 101kD

• Background：
• VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

• Function：
• function:Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,tissue specificity:Widely expressed.,

• Subcellular Location：
• cytosol,plasma membrane,

• Expression：
• Widely expressed.

EZH2 reduction is an essential mechanoresponse for the maintenance of super-enhancer polarization against compressive stress in human periodontal ligament stem cells. Cell Death & Disease Cell Death Dis. 2020 Sep;11(9):1-18 IF Human Human periodontal ligament cell (PDLSCs)

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