• Target：
• CaMKIIδ

• Fields：
• >>ErbB signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>HIF-1 signaling pathway;>>Oocyte meiosis;>>Necroptosis;>>Adrenergic signaling in cardiomyocytes;>>Wnt signaling pathway;>>Axon guidance;>>Circadian entrainment;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Cholinergic synapse;>>Dopaminergic synapse;>>Olfactory transduction;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Glucagon signaling pathway;>>Aldosterone synthesis and secretion;>>Cushing syndrome;>>Gastric acid secretion;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases;>>Amphetamine addiction;>>Tuberculosis;>>Pathways in cancer;>>Proteoglycans in cancer;>>Glioma;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis

• Gene Name：
• CAMK2D

• Protein Name：
• Calcium/calmodulin-dependent protein kinase type II subunit delta

• Human Gene Id：
• 817

• Human Swiss Prot No：
• Q13557

• Mouse Gene Id：
• 108058

• Mouse Swiss Prot No：
• Q6PHZ2

• Rat Gene Id：
• 24246

• Rat Swiss Prot No：
• P15791

• Immunogen：
• Synthesized peptide derived from the Internal region of human CaMKIIδ.

• Specificity：
• CaMKIIδ Polyclonal Antibody detects endogenous levels of CaMKIIδ protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CAMK2D;CAMKD;Calcium/calmodulin-dependent protein kinase type II subunit delta;CaM kinase II subunit delta;CaMK-II subunit delta

• Observed Band(KD)：
• 56kD

• Background：
• The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,miscellaneous:Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,tissue specificity:Expressed in cardiac muscle and skeletal mus

• Subcellular Location：
• Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .

• Expression：
• Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.

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