• Target：
• IL-31Rα

• Fields：
• >>Cytokine-cytokine receptor interaction

• Gene Name：
• IL31RA

• Protein Name：
• Interleukin-31 receptor subunit alpha

• Human Gene Id：
• 133396

• Human Swiss Prot No：
• Q8NI17

• Mouse Swiss Prot No：
• Q8K5B1

• Immunogen：
• Synthesized peptide derived from the Internal region of human IL-31Rα.

• Specificity：
• IL-31Rα Polyclonal Antibody detects endogenous levels of IL-31Rα protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL31RA;CRL3;GPL;Interleukin-31 receptor subunit alpha;IL-31 receptor subunit alpha;IL-31R subunit alpha;IL-31R-alpha;IL-31RA;Cytokine receptor-like 3;GLM-R;hGLM-R;Gp130-like monocyte receptor;Gp130-like receptor;ZcytoR17

• Observed Band(KD)：
• 82kD

• Background：
• The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011],

• Function：
• function:Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.,induction:Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG and lipopolysaccharides.,PTM:N-glycosylated.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 5 fibronectin type-III domains.,subunit:Heterodimer with OSMR. Interacts with JAK1 and STAT3.,tissue specificity:Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14-and CD56-positive blood cells and by macrophages (at protein level).,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, presynaptic cell membrane . Cell projection, axon .

• Expression：
• Expressed in CD14- and CD56-positive blood cells (PubMed:11877449). Expressed in macrophages (PubMed:16461143, PubMed:18439099). Expressed in keratinocytes (PubMed:21261663). Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099). Detected in all of the myelomonocytic lineage (PubMed:14504285). Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353).

Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro Heliyon Niuniu Yang WB Human 1:1000 HaCaT cell

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