• Target：
• NF-L

• Fields：
• >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases

• Gene Name：
• NEFL

• Protein Name：
• Neurofilament light polypeptide

• Human Gene Id：
• 4747

• Human Swiss Prot No：
• P07196

• Mouse Gene Id：
• 18039

• Mouse Swiss Prot No：
• P08551

• Rat Gene Id：
• 83613

• Rat Swiss Prot No：
• P19527

• Immunogen：
• Synthesized peptide derived from the C-terminal region of human NF-L.

• Specificity：
• NF-L Polyclonal Antibody detects endogenous levels of NF-L protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NEFL;NF68;NFL;Neurofilament light polypeptide;NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein

• Observed Band(KD)：
• 61kD

• Background：
• Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],

• Function：
• caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac

• Subcellular Location：
• Cell projection, axon . Cytoplasm, cytoskeleton .

• Expression：
• Amygdala,Brain,Fetal brain cortex,Thalamus,

Electrochemical Quantitation of the Glycosylation Level of Serum Neurofilament Light Chain for the Diagnosis of Neurodegeneration: An Interface-Solution Dual-Path Amplification Strategy ANALYTICAL CHEMISTRY Juan Xiang ELISA Human

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