• Target：
• MCM3

• Fields：
• >>DNA replication;>>Cell cycle

• Gene Name：
• MCM3

• Protein Name：
• DNA replication licensing factor MCM3

• Human Gene Id：
• 4172

• Human Swiss Prot No：
• P25205

• Mouse Swiss Prot No：
• P25206

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human MCM3. AA range:641-690

• Specificity：
• MCM3 Polyclonal Antibody detects endogenous levels of MCM3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MCM3;DNA replication licensing factor MCM3;DNA polymerase alpha holoenzyme-associated protein P1;P1-MCM3;RLF subunit beta;p102

• Observed Band(KD)：
• 89kD

• Background：
• The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],

• Function：
• function:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation.,miscellaneous:Associated with the replication-specific DNA polymerase alpha.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,

• Subcellular Location：
• Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .

• Expression：
• Cervix,Coronary artery,Epithelium,Lymph,Osteosarcoma,Pancre

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