• Target：
• Protein C

• Fields：
• >>Complement and coagulation cascades

• Gene Name：
• PROC

• Protein Name：
• Vitamin K-dependent protein C

• Human Gene Id：
• 5624

• Human Swiss Prot No：
• P04070

• Mouse Swiss Prot No：
• P33587

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human PROC. AA range:181-230

• Specificity：
• Protein C Polyclonal Antibody detects endogenous levels of Protein C protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PROC;Vitamin K-dependent protein C;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV

• Observed Band(KD)：
• 52kD

• Background：
• This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009],

• Function：
• catalytic activity:Degradation of blood coagulation factors Va and VIIIa.,disease:Defects in PROC are the cause of protein C deficiency autosomal dominant (ADPROCD) [MIM:176860]. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.,disease:Defects in PROC are the cause of protein C deficiency autosomal recessive (ARPROCD) [MIM:612304]. ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form l

• Subcellular Location：
• Secreted . Golgi apparatus . Endoplasmic reticulum .

• Expression：
• Plasma; synthesized in the liver.

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