• Target：
• EP1

• Fields：
• >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Human cytomegalovirus infection;>>Pathways in cancer

• Gene Name：
• PTGER1

• Protein Name：
• Prostaglandin E2 receptor EP1 subtype

• Human Gene Id：
• 5731

• Human Swiss Prot No：
• P34995

• Mouse Swiss Prot No：
• P35375

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human PTGER1. AA range:191-240

• Specificity：
• EP1 Polyclonal Antibody detects endogenous levels of EP1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PTGER1;Prostaglandin E2 receptor EP1 subtype;PGE receptor EP1 subtype;PGE2 receptor EP1 subtype;Prostanoid EP1 receptor

• Observed Band(KD)：
• 44kD

• Background：
• The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008],

• Function：
• function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.,PTM:Phosphorylated .,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.

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