• Target：
• CD85c

• Fields：
• >>Osteoclast differentiation;>>B cell receptor signaling pathway

• Gene Name：
• LILRB5

• Protein Name：
• Leukocyte immunoglobulin-like receptor subfamily B member 5

• Human Gene Id：
• 10990

• Human Swiss Prot No：
• O75023

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the N-terminal region of human LILRB5. AA range:21-70

• Specificity：
• CD85c Polyclonal Antibody detects endogenous levels of CD85c protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• LILRB5;LIR8;Leukocyte immunoglobulin-like receptor subfamily B member 5;CD85 antigen-like family member C;Leukocyte immunoglobulin-like receptor 8;LIR-8;CD85c

• Observed Band(KD)：
• 65kD

• Background：
• This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:May act as receptor for class I MHC antigens.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in a natural killer (NK) cells.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Detected in a natural killer (NK) cells.

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