• Target：
• ALR

• Gene Name：
• GFER

• Protein Name：
• FAD-linked sulfhydryl oxidase ALR

• Human Gene Id：
• 2671

• Human Swiss Prot No：
• P55789

• Mouse Gene Id：
• 11692

• Mouse Swiss Prot No：
• P56213

• Rat Gene Id：
• 27100

• Rat Swiss Prot No：
• Q63042

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human GFER. AA range:51-100

• Specificity：
• ALR Polyclonal Antibody detects endogenous levels of ALR protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GFER;ALR;HERV1;HPO;FAD-linked sulfhydryl oxidase ALR;Augmenter of liver regeneration;hERV1;Hepatopoietin

• Observed Band(KD)：
• 24kD

• Background：
• The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.,cofactor:FAD.,function:FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.,similarity:Contains 1 ERV/ALR sulfhydryl oxidase domain.,subunit:Homodimer.,

• Subcellular Location：
• [Isoform 1]: Mitochondrion intermembrane space. Mitochondrion .; [Isoform 2]: Cytoplasm. Secreted.

• Expression：
• Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.

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