• Target：
• CD42d

• Fields：
• >>ECM-receptor interaction;>>Platelet activation;>>Hematopoietic cell lineage

• Gene Name：
• GP5

• Protein Name：
• Platelet glycoprotein V

• Human Gene Id：
• 2814

• Human Swiss Prot No：
• P40197

• Mouse Swiss Prot No：
• O08742

• Rat Gene Id：
• 25259

• Rat Swiss Prot No：
• O08770

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380

• Specificity：
• CD42d Polyclonal Antibody detects endogenous levels of CD42d protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GP5;Platelet glycoprotein V;GPV;Glycoprotein 5;CD42d

• Observed Band(KD)：
• 62kD

• Background：
• Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010],

• Function：
• function:The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.,PTM:The N-terminus is blocked.,similarity:Contains 14 LRR (leucine-rich) repeats.,tissue specificity:Platelets and megakaryocytes.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Platelets and megakaryocytes.

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Enhanced Proliferation of Visualizable Mesenchymal Stem Cell–Platelet Hybrid Cell for Versatile Intracerebral Hemorrhage Treatment ACS Nano Dai-Wen Pang WB,IF，FC Mouse platelets (PLs),mesenchymal stem cells (MSCs),fusion cells(FCs)

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