• Target：
• ASAH3L

• Fields：
• >>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway

• Gene Name：
• ACER2

• Protein Name：
• Alkaline ceramidase 2

• Human Gene Id：
• 340485

• Human Swiss Prot No：
• Q5QJU3

• Mouse Gene Id：
• 230379

• Mouse Swiss Prot No：
• Q8VD53

• Immunogen：
• Synthesized peptide derived from ASAH3L . at AA range: 50-130

• Specificity：
• ASAH3L Polyclonal Antibody detects endogenous levels of ASAH3L protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ACER2;ASAH3L;PP11646;Alkaline ceramidase 2;AlkCDase 2;Alkaline CDase 2;haCER2;Acylsphingosine deacylase 3-like;N-acylsphingosine amidohydrolase 3-like

• Observed Band(KD)：
• 33kD

• Background：
• The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010],

• Function：
• catalytic activity:N-acylsphingosine + H(2)O = a carboxylate + sphingosine.,function:Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.,similarity:Belongs to the alkaline ceramidase family.,

• Subcellular Location：
• Golgi apparatus membrane ; Multi-pass membrane protein .

• Expression：
• Highly expressed in placenta.

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