• Target：
• CD269

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Intestinal immune network for IgA production

• Gene Name：
• TNFRSF17

• Protein Name：
• Tumor necrosis factor receptor superfamily member 17

• Human Gene Id：
• 608

• Human Swiss Prot No：
• Q02223

• Mouse Swiss Prot No：
• O88472

• Immunogen：
• Synthesized peptide derived from the Internal region of human CD269.

• Specificity：
• CD269 Polyclonal Antibody detects endogenous levels of CD269 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TNFRSF17;BCM;BCMA;Tumor necrosis factor receptor superfamily member 17;B-cell maturation protein;CD269

• Observed Band(KD)：
• 20kD

• Background：
• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008],

• Function：
• disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,

• Subcellular Location：
• Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.

• Expression：
• Expressed in mature B-cells, but not in T-cells or monocytes.

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