• Target：
• NFAT5

• Gene Name：
• NFAT5 KIAA0827 TONEBP

• Protein Name：
• NFAT5

• Human Gene Id：
• 10725

• Human Swiss Prot No：
• O94916

• Mouse Swiss Prot No：
• Q9WV30

• Immunogen：
• Synthetic peptide from human protein at AA range: 212-284

• Specificity：
• The antibody detects endogenous NFAT5

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Nuclear factor of activated T-cells 5 (NF-AT5;T-cell transcription factor NFAT5;Tonicity-responsive enhancer-binding protein;TonE-binding protein;TonEBP)

• Molecular Weight(Da)：
• 166kD

• Background：
• The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• alternative products:Experimental confirmation may be lacking for some isoforms,function:Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.,similarity:Contains 1 RHD (Rel-like) domain.,subunit:Does not bind with Fos and Jun transcription factors. But might be capable of forming stable dimers with DNA elements.,tissue specificity:Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.,

• Subcellular Location：
• Nucleus . Cytoplasm . Nuclear distribution increases under hypertonic conditions. .

• Expression：
• Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.

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