• Target：
• TGFβ2

• Fields：
• >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>FoxO signaling pathway;>>Cell cycle;>>Cellular senescence;>>TGF-beta signaling pathway;>>Osteoclast differentiation;>>Hippo signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Leishmaniasis;>>Chagas disease;>>Malaria;>>Toxoplasmosis;>>Amoebiasis;>>Tuberculosis;>>Hepatitis B;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Colorectal cancer;>>Renal cell carcinoma;>>Pancreatic cancer;>>Chronic myeloid leukemia;>>Hepatocellular carcinoma;>>Gastric cancer;>>Inflammatory bowel disease;>>Rheumatoid arthritis;>>Hypertrophic cardiomyopathy;>>Dilated cardiomyopathy;>>Diabetic cardiomyopathy

• Gene Name：
• TGFB2

• Protein Name：
• Transforming growth factor beta-2 (TGF-beta-2) (BSC-1 cell growth inhibitor) (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) (Polyergin)

• Human Gene Id：
• 7042

• Human Swiss Prot No：
• P61812

• Mouse Gene Id：
• 21808

• Mouse Swiss Prot No：
• P27090

• Rat Swiss Prot No：
• Q07257

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TGF beta2. AA range:361-410

• Specificity：
• The antibody detects endogenous TGFβ2

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000,IHC 1:500-200, ELISA 1:10000-20000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Transforming growth factor beta-2 (TGF-beta-2;BSC-1 cell growth inhibitor;Cetermin;Glioblastoma-derived T-cell suppressor factor;G-TSF;Polyergin)

• Observed Band(KD)：
• 47kD,12kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the an

• Function：
• disease:A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with HDAC9. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.,function:TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.,online information:TGF beta-2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

• Subcellular Location：
• [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-2]: Secreted .

• Expression：
• Aorta endothelial cell,Lung,

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