OSM Polyclonal Antibody
- Catalog No.:YT5913
- Applications:IHC;IF;ELISA
- Reactivity:Human;Rat;Mouse;
- Target:
- OSM
- Fields:
- >>Cytokine-cytokine receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway
- Gene Name:
- OSM
- Protein Name:
- Oncostatin-M (OSM)
- Human Gene Id:
- 5008
- Human Swiss Prot No:
- P13725
- Mouse Gene Id:
- 18413
- Mouse Swiss Prot No:
- P53347
- Immunogen:
- Synthetic peptide from human protein at AA range: 50-100
- Specificity:
- The antibody detects endogenous OSM
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Oncostatin-M (OSM)
- Background:
- This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
- Function:
- function:Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST).,similarity:Belongs to the LIF/OSM family.,
- Subcellular Location:
- Secreted.
- Expression:
- Lung,T-cell,
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