• Target：
• CCL17

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway

• Gene Name：
• CCL17 SCYA17 TARC

• Protein Name：
• CCL17

• Human Gene Id：
• 6361

• Human Swiss Prot No：
• Q92583

• Immunogen：
• Synthesized peptide derived from human CCL17 AA range: 21-70

• Specificity：
• This antibody detects endogenous levels of human CCL17

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000, ELISA(peptide)1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• C-C motif chemokine 17 (CC chemokine TARC;Small-inducible cytokine A17;Thymus and activation-regulated chemokine)

• Observed Band(KD)：
• 10kD

• Background：
• This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014],

• Function：
• caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8.,function:Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.,induction:By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes.,online information:CCL17 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.,

• Subcellular Location：
• Secreted.

• Expression：
• Expressed at high levels in thymus and at low levels in the lung, colon and small intestine.

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