VCAM-1 rabbit pAb

  • Catalog No.：YT7839
  • Applications：WB;ELISA
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • VCAM-1
    • Fields：
    • >>NF-kappa B signaling pathway;>>Cell adhesion molecules;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
    • Gene Name：
    • VCAM1 L1CAM
    • Protein Name：
    • VCAM-1
    • Human Gene Id：
    • 7412
    • Human Swiss Prot No：
    • P19320
    • Mouse Swiss Prot No：
    • P29533
    • Immunogen：
    • Synthesized peptide derived from human VCAM-1 AA range: 551-600
    • Specificity：
    • This antibody detects endogenous levels of Human VCAM-1
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Vascular cell adhesion protein 1 (V-CAM 1;VCAM-1;INCAM-100;CD antigen CD106)
    • Molecular Weight(Da)：
    • 81kD
    • Background：
    • This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010],
    • Function：
    • alternative products:Additional isoforms seem to exist,disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificit
    • Subcellular Location：
    • Membrane; Single-pass type I membrane protein.
    • Expression：
    • Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.

    Attributes

    • Code：
    • YT7839
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-11-24
    Order

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