• Target：
• Csk

• Fields：
• >>Epithelial cell signaling in Helicobacter pylori infection

• Gene Name：
• CSK

• Protein Name：
• Tyrosine-protein kinase CSK

• Human Gene Id：
• 1445

• Human Swiss Prot No：
• P41240

• Mouse Gene Id：
• 12988

• Mouse Swiss Prot No：
• P41241

• Rat Gene Id：
• 315707

• Rat Swiss Prot No：
• P32577

• Immunogen：
• Purified recombinant fragment of human Csk expressed in E. Coli.

• Specificity：
• Csk Monoclonal Antibody detects endogenous levels of Csk protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CSK;Tyrosine-protein kinase CSK;C-Src kinase;Protein-tyrosine kinase CYL

• Molecular Weight(Da)：
• 51kD

• References：
• 1. Nat Genet. 2009 Jun;41(6):677-87.
  2. Leuk Res. 2009 Sep;33(9):e168-9.
  3. J Hypertens. 2011 Jan;29(1):62-9.

• Background：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,

• Subcellular Location：
• Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .

• Expression：
• Expressed in lung and macrophages.

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