• Target：
• Rak

• Gene Name：
• FRK

• Protein Name：
• Tyrosine-protein kinase FRK

• Human Gene Id：
• 2444

• Human Swiss Prot No：
• P42685

• Mouse Swiss Prot No：
• Q922K9

• Immunogen：
• Purified recombinant fragment of Rak (aa2-300) expressed in E. Coli.

• Specificity：
• Rak Monoclonal Antibody detects endogenous levels of Rak protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FRK;PTK5;RAK;Tyrosine-protein kinase FRK;FYN-related kinase;Nuclear tyrosine protein kinase RAK;Protein-tyrosine kinase 5

• Molecular Weight(Da)：
• 58kD

• References：
• 1. Int J Cancer. 1993 Jun 19;54(4):571-7.
  2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
  3. Neurosci Lett. 2004 Apr 22;360(1-2):109-11.

• Background：
• The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin.,

• Subcellular Location：
• Cytoplasm . Nucleus . Predominantly found in the nucleus, with a small fraction found in the cell periphery.

• Expression：
• Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

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