• Target：
• Rictor

• Fields：
• >>mTOR signaling pathway

• Gene Name：
• RICTOR

• Protein Name：
• Rapamycin-insensitive companion of mTOR

• Human Gene Id：
• 253260

• Human Swiss Prot No：
• Q6R327

• Mouse Gene Id：
• 78757

• Mouse Swiss Prot No：
• Q6QI06

• Immunogen：
• Purified recombinant fragment of human Rictor expressed in E. Coli.

• Specificity：
• Rictor Monoclonal Antibody detects endogenous levels of Rictor protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• RICTOR;KIAA1999;Rapamycin-insensitive companion of mTOR;AVO3 homolog;hAVO3

• Molecular Weight(Da)：
• 192kD

• References：
• 1. Genes Dev. 2006 Oct 15;20(20):2820-32.
  2. Biochem Biophys Res Commun. 2008 Aug 8;372(4):578-83.

• Background：
• RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],

• Function：
• function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.,

• Subcellular Location：
• cytosol,TORC2 complex,

• Expression：
• Amygdala,Brain,Epithelium,Lymph,

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