Uroplakin III (ABT-UPK3) mouse mAb

    • Catalog No.:YM6138
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human, Mouse
      • Gene Name:
      • UPK3A UPK3
      • Protein Name:
      • Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)
      • Human Gene Id:
      • 7380
      • Human Swiss Prot No:
      • O75631
      • Immunogen:
      • Synthesized peptide derived from human Uroplakin III
      • Specificity:
      • This antibody detects endogenous levels of human Uroplakin III. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Monoclonal, Mouse/IgG1, Lambda
      • Dilution:
      • WB 500-2000 IHC-p 1:100-500
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • -20°C/1 year
      • Background:
      • uroplakin 3A(UPK3A) Homo sapiens This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],
      • Function:
      • disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation
      • Subcellular Location:
      • Membranous, Cytoplasmic
      • Expression:
      • Ureter,Urinary bladder urothelium,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Bladder. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded Bladder. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded Bladder. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded Bladder-High magnification. 1, Antibody was diluted at 1:200(4° overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded Bladder-High magnification. 1, Antibody was diluted at 1:200(4° overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded human prostate Antibody was diluted at 1:200(4° overnight).