IGF1 Receptor (PT0136R) PT® Rabbit mAb
- Catalog No.:YM8077
- Applications:WB;IHC;IF;IP;ELISA
- Reactivity:Human;
- Target:
- IGF-1R
- Fields:
- >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Oocyte meiosis;>>Autophagy - animal;>>Endocytosis;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Focal adhesion;>>Adherens junction;>>Signaling pathways regulating pluripotency of stem cells;>>Long-term depression;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Proteoglycans in cancer;>>Glioma;>>Prostate cancer;>>Melanoma;>>Breast cancer;>>Hepatocellular carcinoma
- Gene Name:
- IGF1R
- Protein Name:
- Insulin-like growth factor 1 receptor
- Human Gene Id:
- 3480
- Human Swiss Prot No:
- P08069
- Mouse Gene Id:
- 16001
- Mouse Swiss Prot No:
- Q60751
- Rat Gene Id:
- 25718
- Rat Swiss Prot No:
- P24062
- Specificity:
- endogenous
- Formulation:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source:
- Monoclonal, rabbit, IgG, Kappa
- Dilution:
- IHC 1:100-200,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200
- Purification:
- Protein A
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- IGF1R;Insulin-like growth factor 1 receptor;Insulin-like growth factor I receptor;IGF-I receptor;CD antigen CD221
- Molecular Weight(Da):
- 154kD
- Observed Band(KD):
- 200kD
- Background:
- This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
- Function:
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.,enzyme regulation:Autophosphorylation activates the kinase activity.,function:This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low a
- Subcellular Location:
- Membranous
- Expression:
- Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney.
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- Antibody-FAQs
- Products Images
- Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-IGF1 Receptor (PT0136R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: LoVo Lane 2: MCF7 Predicted band size: 154kDa Observed band size: 200kDa
- Human bladder carcinoma was stained with Anti-IGF1 Receptor (PT0136R) rabbit antibody