• Target：
• PP2A alpha + beta

• Fields：
• >>mRNA surveillance pathway;>>Sphingolipid signaling pathway;>>Oocyte meiosis;>>Autophagy - other;>>Autophagy - animal;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Tight junction;>>Dopaminergic synapse;>>Long-term depression;>>Chagas disease;>>Hepatitis C;>>Human papillomavirus infection

• Gene Name：
• PPP2CA;PPP2CB

• Protein Name：
• Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PP2A-beta;PP2A-alpha;Replication protein C;RP-C;

• Human Gene Id：
• 5515;5516

• Human Swiss Prot No：
• P67775,P62714

• Mouse Gene Id：
• 19052;19053

• Mouse Swiss Prot No：
• P63330;P62715

• Rat Gene Id：
• 24672;24673

• Rat Swiss Prot No：
• P63331;P62716

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PP2A A;PP2A alpha;PP2A B;PP2A beta;PP2A-alpha;PP2A-beta;PP2AA_HUMAN;PP2Aalpha;PP2AB_HUMAN;PP2Abeta;PP2Ac;PP2CA;PP2Calpha;PP2CB;PPP2CA;PPP2CB;Protein phosphatase 2 catalytic subunit alpha isoform;Protein phosphatase 2 catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Replication protein C;RP C;RP-C;RPC;Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine protein phosphatase 2A catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;

• Molecular Weight(Da)：
• 36kD

• Observed Band(KD)：
• 36kD

• Background：
• This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008],

• Function：
• PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.

• Subcellular Location：
• Cytoplasm

• Expression：
• Fibroblast,Liver,Lung,Placenta,Testis,Uterus,baseline

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