• Target：
• Integrin β2

• Fields：
• >>Rap1 signaling pathway;>>Phagosome;>>Hippo signaling pathway;>>Cell adhesion molecules;>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Natural killer cell mediated cytotoxicity;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Pertussis;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Amoebiasis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Human T-cell leukemia virus 1 infection;>>Rheumatoid arthritis;>>Viral myocarditis

• Gene Name：
• ITGB2

• Protein Name：
• Integrin beta-2

• Human Gene Id：
• 3689

• Human Swiss Prot No：
• P05107

• Mouse Gene Id：
• 16414

• Mouse Swiss Prot No：
• P11835

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CD18/ITGB2 around the phosphorylation site of Thr758. AA range:720-769

• Specificity：
• Phospho-Integrin β2 (T758) Polyclonal Antibody detects endogenous levels of Integrin β2 protein only when phosphorylated at T758.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ITGB2;CD18;MFI7;Integrin beta-2;Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta;Complement receptor C3 subunit beta;CD antigen CD18

• Observed Band(KD)：
• 170kD

• Background：
• This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

• Function：
• disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

• Expression：
• Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).

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