• Target：
• BMP-3

• Fields：
• >>Cytokine-cytokine receptor interaction

• Gene Name：
• BMP3

• Protein Name：
• Bone morphogenetic protein 3

• Human Gene Id：
• 651

• Human Swiss Prot No：
• P12645

• Mouse Gene Id：
• 110075

• Mouse Swiss Prot No：
• Q8BHE5

• Rat Gene Id：
• 25667

• Rat Swiss Prot No：
• P49002

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human BMP-3. AA range:257-306

• Specificity：
• BMP-3 Polyclonal Antibody detects endogenous levels of BMP-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BMP3;BMP3A;Bone morphogenetic protein 3;BMP-3;Bone morphogenetic protein 3A;BMP-3A;Osteogenin

• Observed Band(KD)：
• 53kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],

• Function：
• function:Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.,induction:Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.,online information:Bone morphogenetic protein 3 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in adult and fetal cartilage.,

• Subcellular Location：
• Secreted.

• Expression：
• Expressed in adult and fetal cartilage.

GATA4-driven miR-206-3p signatures control orofacial bone development by regulating osteogenic and osteoclastic activity. Theranostics Theranostics. 2021; 11(17): 8379–8395 WB Mouse 1:2000 orofacial mesenchymal stem cells

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