Cadherin-8 Polyclonal Antibody

    • Catalog No.:YT0603
    • Applications:WB;IHC;IF;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • Cadherin-8
      • Gene Name:
      • CDH8
      • Protein Name:
      • Cadherin-8
      • Human Gene Id:
      • 1006
      • Human Swiss Prot No:
      • P55286
      • Mouse Swiss Prot No:
      • P97291
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human CDH8. AA range:491-540
      • Specificity:
      • Cadherin-8 Polyclonal Antibody detects endogenous levels of Cadherin-8 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • CDH8;Cadherin-8
      • Observed Band(KD):
      • 90kD
      • Background:
      • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.,
      • Subcellular Location:
      • Cell membrane; Single-pass type I membrane protein.
      • Expression:
      • Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.
      • Products Images
      • Western Blot analysis of RAW264.7 cells using Cadherin-8 Polyclonal Antibody
      • Immunofluorescence analysis of COS7 cells, using CDH8 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CDH8 Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from RAW264.7 cells, using CDH8 Antibody. The lane on the right is blocked with the synthesized peptide.