• Target：
• FAST

• Gene Name：
• FASTK

• Protein Name：
• Fas-activated serine/threonine kinase

• Human Gene Id：
• 10922

• Human Swiss Prot No：
• Q14296

• Mouse Swiss Prot No：
• Q9JIX9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410

• Specificity：
• FAST Polyclonal Antibody detects endogenous levels of FAST protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• FASTK;Fas-activated serine/threonine kinase;FAST kinase

• Observed Band(KD)：
• 61kD

• Background：
• The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].,function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.,PTM:Phosphorylated on serine/threonine.,similarity:Belongs to the FAST protein kinase family.,similarity:Contains 1 RAP domain.,subunit:Interacts with TIA-1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,

• Subcellular Location：
• [Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. .

• Expression：
• Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

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