• Target：
• IRAK-2

• Fields：
• >>Neurotrophin signaling pathway;>>Tuberculosis

• Gene Name：
• IRAK2

• Protein Name：
• Interleukin-1 receptor-associated kinase-like 2

• Human Gene Id：
• 3656

• Human Swiss Prot No：
• O43187

• Mouse Swiss Prot No：
• Q8CFA1

• Immunogen：
• Synthesized peptide derived from the Internal region of human IRAK-2.

• Specificity：
• IRAK-2 Polyclonal Antibody detects endogenous levels of IRAK-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IRAK2;Interleukin-1 receptor-associated kinase-like 2;IRAK-2

• Observed Band(KD)：
• 70kD

• Background：
• IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008],

• Function：
• caution:Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.,tissue specificity:Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leuko

• Subcellular Location：
• nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,

• Expression：
• Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.

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