• Target：
• PRC

• Gene Name：
• PPRC1

• Protein Name：
• Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

• Human Gene Id：
• 23082

• Human Swiss Prot No：
• Q5VV67

• Mouse Gene Id：
• 226169

• Mouse Swiss Prot No：
• Q6NZN1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PPRC1. AA range:1609-1658

• Specificity：
• PRC Polyclonal Antibody detects endogenous levels of PRC protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PPRC1;KIAA0595;Peroxisome proliferator-activated receptor gamma coactivator-related protein 1;PGC-1-related coactivator;PRC

• Molecular Weight(Da)：
• 178kD

• Background：
• The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

• Function：
• function:Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.,induction:Up-regulated by serum (at protein level).,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Colocalizes with NRF1.,subunit:Interacts with CREB1 and NRF1.,tissue specificity:Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.,

• Subcellular Location：
• Nucleus . Colocalizes with NRF1. .

• Expression：
• Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.

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