• Target：
• PSMD12

• Fields：
• >>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection

• Gene Name：
• PSMD12

• Protein Name：
• 26S proteasome non-ATPase regulatory subunit 12

• Human Gene Id：
• 5718

• Human Swiss Prot No：
• O00232

• Mouse Gene Id：
• 66997

• Mouse Swiss Prot No：
• Q9D8W5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PSMD12. AA range:151-200

• Specificity：
• PSMD12 Polyclonal Antibody detects endogenous levels of PSMD12 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PSMD12;26S proteasome non-ATPase regulatory subunit 12;26S proteasome regulatory subunit RPN5;26S proteasome regulatory subunit p55

• Observed Band(KD)：
• 50kD

• Background：
• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding

• Function：
• function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit p55 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex.,

• Subcellular Location：
• proteasome complex,nucleoplasm,cytoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,extracellular exosome,

• Expression：
• Brain,Muscle,Platelet,Testis,Tongue,

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