• Target：
• Tie-1

• Gene Name：
• TIE1

• Protein Name：
• Tyrosine-protein kinase receptor Tie-1

• Human Gene Id：
• 7075

• Human Swiss Prot No：
• P35590

• Mouse Gene Id：
• 21846

• Mouse Swiss Prot No：
• Q06806

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TIE1. AA range:851-900

• Specificity：
• Tie-1 Polyclonal Antibody detects endogenous levels of Tie-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TIE1;TIE;Tyrosine-protein kinase receptor Tie-1

• Observed Band(KD)：
• 130kD

• Background：
• This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Probable protein tyrosine-kinase transmembrane receptor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 fibronectin type-III domains.,tissue specificity:Specifically expressed in developing vascular endothelial cells.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Specifically expressed in developing vascular endothelial cells.

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