• Target：
• RHEB

• Fields：
• >>Phospholipase D signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Cellular senescence;>>Thermogenesis;>>Insulin signaling pathway;>>Thyroid hormone signaling pathway;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Choline metabolism in cancer

• Gene Name：
• RHEB RHEB2

• Protein Name：
• RHEB

• Human Gene Id：
• 6009

• Human Swiss Prot No：
• Q15382

• Mouse Gene Id：
• 19744

• Mouse Swiss Prot No：
• Q921J2

• Rat Swiss Prot No：
• Q62639

• Immunogen：
• Synthetic Peptide of RHEB

• Specificity：
• This antibody detects endogenous levels of RHEB Polyclonal Antibody at Human;Mouse;Rat;Predicted:Cow, It doesn't reacte with total protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Ras homolog enriched in brain

• Observed Band(KD)：
• 20kD

• Background：
• This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008],

• Function：
• function:Not known; binds GTP and exhibits intrinsic GTPase activity.,similarity:Belongs to the small GTPase superfamily. Rheb family.,tissue specificity:Ubiquitous. Highest levels observed in skeletal and cardiac muscle.,

• Subcellular Location：
• Endomembrane system ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .

• Expression：
• Ubiquitous. Highest levels observed in skeletal and cardiac muscle.

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