• Target：
• Thrombospondin 1

• Fields：
• >>Rap1 signaling pathway;>>p53 signaling pathway;>>Phagosome;>>PI3K-Akt signaling pathway;>>TGF-beta signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Malaria;>>Human papillomavirus infection;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Bladder cancer

• Gene Name：
• THBS1 TSP TSP1

• Protein Name：
• Thrombospondin 1

• Human Gene Id：
• 7057

• Human Swiss Prot No：
• P07996

• Immunogen：
• Synthesized peptide derived from human Thrombospondin 1

• Specificity：
• This antibody detects endogenous levels of human Thrombospondin 1

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Thrombospondin-1

• Observed Band(KD)：
• 130kD

• Background：
• thrombospondin 1(THBS1) Homo sapiens The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008],

• Function：
• function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 TSP type-1 domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homotrimer; disulfide-linked.,

• Subcellular Location：
• Secreted . Cell surface . Secreted, extracellular space, extracellular matrix . Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity). .

• Expression：
• Aorta endothelial cell,Endothelial cell,Liver,Plasma,Platelet,Saliva,

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